科研情况简介

主要从事新药研发的工作。近年来先后主持省、市等科研项目2项及广东省科学院“百人计划”D类项目1项。发表SCI论文20篇，其中第一作者(含共同)发表11篇（中科院一区论文8篇）, 申请中国发明专利30件，其中授权13件，申请PCT专利4件。

社会任职

中国化学会会员、广州市农村科技特派员

研究方向

主要从事抗肿瘤药物、免疫炎症性疾病的药物研究

学术论著

1. Gang Li#, Yanting Wu#, Yali Zhang#, Huamin Wang, Mengjie Li, Dengqin He, Wen Guan, Hongliang Yao*, Research progress on phosphatidylinositol 4-kinase inhibitors, Biochemical Pharmacology, 2024, 220, 115993. (IF: 5.8, 中科院二区)

2. Liyan Song#, Gang Li#, Wen Guan#, Zhijun Zeng, Yanghui Ou, Tongchao Zhao, Jiayu Li, Dengqin He, Xiangxiang Fang, Yali Zhang, Jia-qiang Wu, Rongbiao Tong*, Hongliang Yao*, Design, synthesis and anti-inflammatory activity study of lansiumamide analogues for treatment of acute lung injury, Biomedicine & Pharmacotherapy, 2023, 166, 115412. (IF: 7.5, 中科院一区)

3. Gang Li#, Jia-Qiang Wu#, Xiaojia Cai#, Wen Guan, Zhijun Zeng, Yanghui Ou, Xiaoyun Wu, Jiayu Li, Xiangxiang Fang, Jinling Liu, Yali Zhang, Huamin Wang, Canqiang Yin, Hongliang Yao*, Design, synthesis, and biological evaluation of diaryl heterocyclic derivatives targeting tubulin polymerization with potent anticancer activities, European Journal of Medicinal Chemistry, 2023, 252, 115284. (IF: 7.088, 中科院一区)

4. Gang Li, Dengqin He, Xiaojia Cai, Wen Guan, Yali Zhang, Jia-Qiang Wu, Hongliang Yao*, Advances in the development of phosphodiesterase-4 inhibitors, European Journal of Medicinal Chemistry, 2023, 250, 115195. (IF: 7.088, 中科院一区)

5. Yichang Ren#, Yuxi Wang#, Gang Li#, Zherong Zhang, Lingling Ma, Binbin Cheng, Jianjun Chen*. Discovery of Novel Benzimidazole and Indazole Analogues as Tubulin Polymerization Inhibitors with Potent Anticancer Activities, Journal of Medicinal Chemistry, 2021, 64, 4498-4515. (共同一作, IF: 8.039, 中科院一区)

6. Gang Li, Wenqing Qi, Xiaoxun Li, Jinwu Zhao, Meihua Luo, Jianjun Chen*. Recent Advances in c-Jun N-Terminal Kinase (JNK) Inhibitors, Current Medicinal Chemistry, 2021, 28(3), 607-627. (IF: 4.53, JCR二区, 中科院三区)        

7. Gang Li, Yuxi Wang, Ling Li, Yichang Ren, Xin Deng, Jin Liu, Wei Wang, Meihua Luo, Shuwen Liu, Jianjun Chen*. Design, synthesis, and bioevaluation of pyrazolo[1,5-α]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities, European Journal of Medicinal Chemistry, 2020, 202, 112519. (IF: 6.514, 中科院一区)                                  

8. Gang Li, Haodong Tang, Chuanfeng Liu, Xiaoyu Liao, Sicong Li, Zhengning Shu, Hui Yu, Peng Yang*, One-step synthesis of methylene-bridged bis-carbazole and evaluation of its antitumor activity and G-quadruplex DNA binding property, Bioorganic Chemistry, 2019, 90, 103074. (IF: 4.831, 中科院一区)

9. Gang Li, Xiaoyu Song, Hui Yu, Chun Hu, Mingzhe Liu, Jie Cai, Liang Zhao, Yan Chen, Peng Yang*, Supramolecular recognition of A-tracts DNA by calix[4]carbazole, Sensors and Actuators B: Chemical, 2018, 259, 177-182. (IF: 6.393, 中科院一区)

10. Gang Li, Liang Zhao, Peng Yang*, Zhaozheng Yang, Zhangmin Tian, Yan Chen, Hongyan Shen, Chun Hu*, Engineering 1,3-Alternated Calixcarbazole for Recognition and Sensing of Bisphenol F in Water, Analytical Chemistry, 2016, 88, 10751-10756. (IF: 6.35, 中科院一区)

11. Gang Li, Xue Zhou, Peng Yang*, Yong Jian, Tuo Deng, Hongyan Shen, Ying Bao, Synthesis of a novel methylene-bridged biscarbazole derivative and evaluation of its DNA and nucleotide binding properties, Tetrahedron Letters, 2014, 55, 7054-7059. (IF: 2.259, 中科院三区)

发明专利

1. 陈文华; 姚宏亮; 邱响; 关文; 李刚; 张亚莉; 吴艳婷; 文明, 对叶百部多糖及其制备方法和应用, ZL202310846536.4     

2. 姚宏亮; 李刚; 关文; 童荣标; 宋立彦; 欧扬慧; 曾芷筠; 李嘉裕; 何登芹; 张亚莉, 顺式烯酰胺衍生物及其在制备抗炎药物中的应用, ZL202310481210.6                 

3. 姚宏亮; 李刚; 关文; 童荣标; 宋立彦; 曾芷筠; 欧扬慧; 李嘉裕; 何登芹; 张亚莉, 顺式烯酰胺类衍生物在制备抗菌药物中的应用, ZL202310481215.9

4. 李刚; 姚宏亮; 关文; 曾芷筠; 欧扬慧; 张亚莉, 3,4,5-三甲氧基苯基衍生物及其应用, ZL202211292532.8      

5. 关文; 姚宏亮; 曾芷筠; 李刚; 张亚莉, 柚皮苷二氢查尔酮在制备治疗肺纤维化药物中的应用, ZL202211262591.0    

6. 姚宏亮; 杨晶; 李刚; 尹灿强; 陈冠业; 关文; 王华敏; 欧扬慧; 张亚莉; 曾芷筠, 一种螺环螺缩酮类化合物的制备方法, ZL202210138354.7   

7. 姚宏亮; 关文; 李刚; 杨晶; 王华敏; 欧扬慧; 莫锦榆; 张亚莉; 曾芷筠, 一种螺环螺缩酮类化合物及其在制备抗疟原虫药物中的应用, ZL202210137536.2                                 

8. 姚宏亮; 李刚; 潘文俊; 关文; 张亚莉; 王华敏, 双取代苯并二氢吡喃酮合成方法及治疗COPD等肺部炎症中应用, ZL202111129637.7

9. 姚宏亮; 王华敏; 周楠; 李刚; 张亚莉; 关文, 单取代二氢色原酮合成方法及治疗COPD等肺部炎症中应用, ZL202111129639.6   

10. 姚宏亮; 李刚; 潘文俊;王华敏; 关文; 张亚莉, 查尔酮衍生物及其用途, ZL202110302392.7  

11. 姚宏亮; 李刚; 潘文俊;王华敏; 关文; 张亚莉, 二氢色原酮衍生物及其合成方法和用途, ZL202110303737.0   

12. 李刚; 陈建军; 任益昌; 姚宏亮; 王华敏; 关文, 7-(3,4-二甲氧基-5-硒甲基苯基)-吡咯并[2, 3-d]嘧啶及其应用, ZL202110235392.X

13. 陈建军; 李刚; 邓欣; 任益昌; 李玲, 一种7-(三甲氧基苯基)-吡咯并[2, 3-d]嘧啶及其应用, ZL2019108330613.0

科技奖项

沈阳市自然科学学术成果三等奖，2019年，排名：第二。