科研情况简介

主要从事人类重大疾病非人灵长类模型制备及机制方面研究。主持国家科技重点专项子任务1项，主持国家自然科学基金青年项目1项及广东省科学院人才项目1项，参与国家级及省/市级科研项目10余项。近年来发表期刊学术论文20多篇,申请国家发明专利4件（其中授权2件）；参编中文专著1本；参编备案企业标准2个。

研究方向

非人灵长类动物疾病模型制备及发病机制研究

学术论著

1. Gao JM, Xia SY, Hide G, Li BH, Liu YY, Wei ZY, Zhuang XJ, Yan Q, Wang Y, Yang W, Chen JH, Rao JH. Multiomics of parkinsonism cynomolgus monkeys highlights significance of metabolites in interaction between host and microbiota. NPJ Biofilms Microbiomes. 2024 Jul 26;10(1):61. doi: 10.1038/s41522-024-00535-3.

2. Tian P#, Gao J#, Liang L, Cui B, Hu Q, Zhou W, Li B, Liu Y, Chen T, Rao J, Wei H. Fecal Microbiota Transplantation Could Improve Chronic Diarrhea in Cynomolgus Monkey by Alleviating Inflammation and Modulating Gut Microbiota. Biomedicines. 2022 Nov 23;10(12):3016. doi: 10.3390/biomedicines10123016.

3. Jiang-Mei Gao, Jun-Hua Rao, Zhi-Yuan Wei, Shou-Yue Xia, Li Huang, Ming-Tian Tang, Geoff Hide, Ting-Ting Zheng, Jia-Huan Li, Guo-An Zhao, Yun-Xiao Sun, Jian-Huan Chen. Transplantation of Gut Microbiota from High-Fat-Diet-Tolerant Cynomolgus Monkeys Alleviates Hyperlipidemia and Hepatic Steatosis in Rats. Frontiers in Microbiology, 2022.13, 876043.

4. 陈衍#，高江梅#，赵世坤，李比海，饶军华，杨世华。无卵黄冷冻液冷冻食蟹猴精液方法的优化。中国实验动物学报。2022.30：01。

5. Gao JM, Yi SQ, Geng GQ, Xu ZS, Hide G, Lun ZR, Lai DH. Infection with Trypanosoma lewisi or Trypanosoma musculi may promote the spread of Toxoplasma gondii. Parasitology. 2021 May;148(6):703-711. doi: 10.1017/S0031182021000196.

6. Gao JM, Qian ZY, Hide G, Lai DH, Lun ZR, Wu ZD. Human African trypanosomiasis: the current situation in endemic regions and the risks for non-endemic regions from imported cases. Parasitology. 2020 Aug;147(9):922-931. doi: 10.1017/S0031182020000645. 

7. Chen YF, Liao LF, Wu N, Gao JM, Zhang P, Wen YZ, Hide G, Lai DH, Lun ZR. Species identification and phylogenetic analysis of Leishmania isolated from patients, vectors and hares in the Xinjiang Autonomous Region, The People's Republic of China. PLoS Negl Trop Dis. 2021 Dec 17;15(12):e0010055. doi: 10.1371/journal.pntd.0010055. 

8. Wang ZJ, Yu SM, Gao JM, Zhang P, Hide G, Yamamoto M, Lai DH, Lun ZR. High resistance to Toxoplasma gondii infection in inducible nitric oxide synthase knockout rats. iScience. 2021 Oct 15;24(11):103280. doi: 10.1016/j.isci.2021.103280. 

9. Langui Song, Jiangmei Gao*, Zhongdao Wu*. Laboratory-acquired infections with Brucella bacteria in China. Biosafety and Health. 2021. 3: 101-104.

10. Chen YF, Yu SF, Wu CY, Wu N, Shen J, Shen J, Gao JM, Wen YZ, Hide G, Lai DH, Lun ZR. Innate Resistance to Leishmania amazonensis Infection in Rat Is Dependent on NOS2. Front Microbiol. 2021 Oct 29;12:733286. doi: 10.3389/fmicb.2021.733286.

11. Jiang-Mei Gao, Zhi-Hui He, Yi-Ting Xie, Geoff Hide, De-Hua Lai, Zhao-Rong Lun. The association between Toxoplasma gondii infection and postpartum blues. Journal of Affective Disorders. 2019. 250, 404-409.

12. Gao JM, Truc P, Desquesnes M, Vincendeau p, Courtois P, Zhang X, Li SJ, Jittapalapong S*, Lun ZR. A preliminary serological study of Trypanosoma evansi and Trypanosoma lewisi in a Chinese human population. Agriculture and Natural Resources. 2018.52, 612-616.

13. Gao JM, Xie YT, Xu ZS, Chen H, Shen JL, Hide G, Lai DH*, Lun ZR*. Genetic analyses of Chinese isolates of Toxoplasma gondii reveal a third clonal lineage with high virulence to murine hosts. Vet. Parasitol. 2017. 241, 52-60.

14. Gao JM, Yi SQ, Wu MS, Geng GQ, Shen JL, Lu FL, Hide G, Lai DH*, Lun ZR*. Investigation of infectivity of neonates and adults from different rat strains to Toxoplasma gondii Prugniaud shows both variation which correlates with iNOS and Arginase-1 activity and increased susceptibility of neonates to infection. Exp. Parasitol. 2015. 149, 47-53. 

15. Chen ZW#, Gao JM#, Huo XX, Wang L, Yu L, Halm-Lai F, Xu YH, Song WJ, Hide G, Shen JL, Lun ZR*. Genotyping of Toxoplasma gondii isolates from cats in different geographic regions of China. Vet. Parasitol. 2011.183, 166-170.

16. Xie YT, Gao JM, Wu YP, Tang P, Hide G, Lai DH*, Lun ZR*. Recombinant α-actinin subunit antigens of Trichomonas vaginalis as potential vaccine candidates in protecting against trichomoniasis. Parasite vector. 2017. 10:83.

17. Guo HM, Gao JM, Luo YL, Wen YZ, Zhang YL, Hide G, Zhou WL, Ayala FJ, Lun ZR*. Infection by Toxoplasma gondii, a severe parasite in neonates and AIDS patients, causes impaired anion secretion in airway epithelia. PNAS. 2015. 112:4435-4440.

18. Wang T, Gao JM, Yi SQ, Geng GQ, Gao XJ, Shen JL, Lu FL, Wen YZ, Hide G, Lun ZR*. Toxoplasma gondii infection in the peritoneal macrophages of rats treated with glucocorticoids. Parasitol Res. 2014. 113:351-358.

发明专利

1.一种日本血吸虫中间宿主钉螺感染诊断的检测方法（ZL201910605101.4）。

2.一种具有护肝作用的巨球菌制剂及其应用（ZL202111060859.8）。