野生动物疫病与免疫研究中心

2018年野生动物疫病与免疫研究中心组建，引进珠江学者领军人才1名，广东省科学院“百人计划”C类人才1名，广东省科学院“百人计划”D类人才1名，现有人员37人，其中研究员2名，副研究员5名，助理研究员4名，研究实习员1名，研究生23名。研究中心以国家和广东省战略需求为导向，旨在聚焦现代农业、保护生物学等领域国际前沿与研究热点，围绕野生动物健康与病原生物学、环境微生物资源开发和生态治理、耐药性微生物与公共卫生健康核心科学问题，开展精准化、系统化的基础应用研究，为广东省野生动物保护、养殖业健康发展、生态环境治理和公共卫生安全服务。

     联系人：李老师；                联系方式：020-89100920

科研方向

　　1.微生物病原生态学

　　2.野生动物疫病防控与免疫研究

3.野生动物新发病毒感染与免疫研究

科研团队　　

  微生物病原生态学团队负责人： 王承民

　　王承民，博士生导师，广东省科学院“引进领军人才”，华南农业大学和河北农业大学硕士生导师。。1996-2003年在河北农业大学获得学士和硕士学位，2007-2010年在中国科学院动物研究所获得理学博士学位，2003-2007年在河南科技学院工作，2010-2018年在中国科学院动物研究所工作（2013年美国USDA学术交流），2018年至今在广东省科学院动物研究所工作。近年来，主持或参加科技部十一五、十二五和十三五重点研发计划，国家自然科学基金、中国科学院先导A等项目，在Cell Reports, Journal of Infectious Diseases, Reviews In Medical Virology，Frontiers in Cellular and Infection Microbiology, Frontiers in genetics, Journal of wildlife diseases,科学通报，生物化学与生物物理进展等发表文章84篇，其中SCI论文57篇。申请发明专利23件，包括授权2件国际发明专利）和12件中国发明专利，编写著作9部，其中英文著作1部，参与制定标准2项。

　野生动物疫病防控与免疫研究 团队负责人 ：陈金平

研究员，博士生导师。现任广东省科学院动物研究所党委书记、所长。1999年-2002年获得哈尔滨师范大学动物学硕士学位，2002年-2005年获得中国科学院动物研究所生态学博士学位。1997年-2002年，在中国水产科学研究院黑龙江水产研究所工作；2005年-2006年，在中国科学院广州生物医药与健康研究院工作，期间在法国国家自然博物馆从事合作研究；2006年至今在广东省科学院动物研究所工作；2014年-2015年，作为访问学者在美国康奈尔大学兽医学院从事分子疫苗相关研究。近年来主持国家、省、市等各类科研项目15项；获得获广东省科学技术二等奖1项，广东省自然科学二等奖1项，梁希林业科学技术科技进步二等奖1项；发表学术论文117篇，其中SCI收录 90 篇。授权国家发明专利15件。　

野生动物新发病毒感染与免疫研究 团队负责人: 刘全　

研究员，博士生导师，现任野生动物新发病毒感染与免疫研究团队首席。国家重点研发项目首席科学家；广东省珠江人才计划领军人才；中国畜牧兽医学会家畜寄虫学分会常务理事。1997年毕业于解放军农牧大学，获学士学位；2000年毕业于解放军军需大学，获博士学位；曾任军事科学院军事医学研究院军事兽医研究所研究员。从事人兽共患寄生虫学及新发虫媒疫病研究，发现分离鉴定新型人兽共患虫媒病毒，命名为阿龙山病毒（Alongshan virus, ALSV）和松岭病毒（Songling virus, SGLV)。在New England Journal of Medicine，Lancet Infect Dis，Lancet HIV，Emerg Infect Dis等期刊以通讯或第一作者发表SCI论文80余篇，获得省自然科学一等奖、二等奖等科研奖励6项。主持国家重点研发及国家自然科学基金等项目10余项。

　　研究组：

　　1.微生物与合成生物学研究组 组长：王承民 副研究员

　　微生物病原生态学研究组于2018年9月成立，围绕微生物开展研究工作，主要设置微生物耐药与公共卫生安全、环境微生物与生态治理、噬菌体资源与产业化等三个研究方向，基于微生物生物学特性、微生物基因组学、转录组学等手段，开展了耐药性细菌在野生动物-家养动物-人-环境 生态圈的扩散、环境微生物生物表型和基因组特征等工作，现有人员10人，其中研究生9人，发表SCI文章57篇，授权专利17件，其中4件国际专利。

　　2.野生动物疫病防控研究组 组长：陈金平 研究员

　　野生动物疫病防控研究组共20人，其中博士7人，本科1人，其他12人，由高级职称4人，助理研究员3人，研究实习员1人，博士研究生2人，硕士研究生10人组成，具有动物学、基因组学、遗传育种学、分子生物学、生物技术等多学科背景，是一支年轻的团队。

  3. 野生动物新发病毒感染与免疫研究组 组长：刘全 研究员 

    野生动物新发病毒感染与免疫研究组共8人，其中研究员1名，副研究员1名，助理研究员1名，博士研究生3名，硕士研究生2名。具有病毒学、预防兽医学学、人兽共患传染病学、寄生虫病学、分子生物学、生物技术等多学科背景，是一支朝气蓬勃的团队。

团队照片

主要成果　　

    本团队共主持国际、国家、省、市等各类项目30余项。共发表SCI论文281篇；授权国家发明专利32件，其中国际发明专利5件；获省自然科学一等奖、二等奖等科研奖励7项，广东省科学技术二等奖1项，梁希林业科学技术科技进步二等奖1项。

科技奖项

　　1.2018年，“我国鲟鱼资源评价、性腺发育研究及应用”获2017年度广东省科技进步二等奖。

2.2019年，“蝙蝠特殊生存策略的机理研究”获2018年度广东省自然科学奖二等奖。

3.2024年，“穿山甲种群保育与恢复技术研究”获2023年度梁希林业科学技术科技进步二等奖。

获奖照片

　　学术论文：

1.Han Q,Yu YP, Sun HB,Zhang XJ,Liu P,Deng JF,Hu XY, Chen JP*, Proteomics and Microbiota Conjoint Analysis in the Nasal Mucus: Revelation of Differences in Immunological Function in Manis javanica and Manis pentadactyla. animals, 2024, 14, 2683.

2.Mujiao Xie, Mei Lv, Zhiwen Zhao, Linmiao Li, Haiying Jiang, Yepin Yu, Xiujuan Zhang, Ping Liu, Jinping Chen*. New insights of bacterial and eukaryotic phenotypes on the plastics collected from the typical natural habitat of the endangered crocodile lizard, Ecotoxicology and Environmental Safety, 2024, 280:116541

3.Xie MJ, Lv M, Zhao ZW, Li LM, Jiang HY, Yu YP, Zhang XJ, Liu P, Chen JP*,Plastisphere characterization in habitat of the highly endangered Shinisaurus crocodilurus: bacteria composition, assembly, function and the comparison with surrounding environment, Science of the Total Environment, 2023, 900: 165807.

4.Hafiz Ishfaq Ahmad, Laraib Jameel, Quratulain Zahra, Jiabin Zhou, Linmiao Li, Xiujuan Zhang, Shakeel Ahmed, Daoud Ali, Gokhlesh Kumar, Aleena Safdar, Farhan Abbas, Jinping Chen. Molecular Evolution of Interferon-Epsilon (IFNε) Pseudogene Modulates Innate and Specific Antiviral Immunity in Manis javanica, Journal of Zoological Systematics and Evolutionary Research, 2023, https://doi.org/10.1155/2023/2949008

5.Hafiz Ishfaq Ahmad,* , Faheem Ahmed Khan, Musarrat Abbas Khan, Safdar Imran ,Rana Waseem Akhtar, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Jinping Chen,* Molecular Evolution of the Bactericidal/Permeability-Increasing Protein (BPIFA1) Regulating the Innate Immune Responses in Mammals, Genes 2023, 14, 15.

6.Yide Guo#, Hualing Chen#, Ping Liu, Fumin Wang, Linmiao Li, Mingbin Ye, Wenge Zhao*, Jinping Chen*. The Effect of ulcer to shell and Intestinal Mycobiota of captive juvenile green sea turtles, Frontiers in Veterinary Science, 2022, 9:1039519.   

7.Wenjing Jiao*, Lina Liu, Zhiliao Zeng, Linmiao Li and Jinping Chen*, Differences of gut microbes in captive Pangolins and the effects of captive breeding, Frontiers in Microbiology, 2022, 13:1053925.

8.Yuanni Shi#, Linmiao Li#, Jiabin Zhou, Yan Hua, Zhiliao Zeng, Ziguo Yuan*, Jinping Chen*. Detection of a novel Pestivirus strain in Java ticks (Amblyomma javanense) and the hosts Malayan pangolin (Manis javanica) and Chinese pangolin (Manis pentadactyla), Frontiers in Microbiology, 2022, 13:988730.

9.Xiujuan Zhang, Wenhua Wu, Jiabin Zhou, Linmiao Li, Haiying Jiang, Jinping Chen*. MiR-34b/c play a role in early sex diferentiation of Amur sturgeon, Acipenser schrenckii, Frontiers in Zoology, 2022, 19:23

10.Xiujuan Zhang, Guanyu Li, Jiabin Zhou, Mei Lv, Linmiao Li, Jinping Chen*. Full length gonad transcriptome analysis of Amur sturgeon Dmrt family genes identification, characterization, and expression patterns during gonadal differentiation, Fish Physiol Biochem, 2022, 48:839–852.

11.Ahmad HI*, Jabbar A, Mushtaq N, Javed Z, Hayyat MU, Bashir J, Naseeb I, Abideen ZU, Ahmad N, Chen J*.Immune Tolerance vs. Immune Resistance: The Interaction Between Host and Pathogens in Infectious Diseases. 2022, Front. Vet. Sci. 9:827407.

12.Ping Liu, Haiying Jiang, Linmiao Li, Jiabin Zhou, Wenzhong Huang, Jinping Chen*. The assembled and annotated genome of the masked palm civet (Paguma larvata), GigaScience, 2022, 11, 1–9.

13.Linmiao Li#, Libiao Zhang#, Jiabin Zhou, Xiangyang He, Yepin Yu, Ping Liu, Wenzhong Huang, Zuofu Xiang*, Jinping Chen*. Epidemiology and Genomic Characterization of Two Novel SARS-Related Coronaviruses in Horseshoe Bats from Guangdong, China. mBio, 2022, 28, 13(3):e0046322.

14.Tianhang Lv#, Xiaoshan Wang#, Chao Yu#, Zhifeng Wang#, Rong Xiang#, Linmiao Li,Yue Yuan, Yuhang Wang, Xiaoyu Wei, Yeya Yu, Xiangyang He, Libiao Zhang, Qiuting Deng, Peiying Wu, Yong Hou, Jinping Chen*, Chuanyu Liu*, Gary Wong*, Longqi Liu*. A map of bat virus receptors derived from single-cell multiomics, Scientific data, 2022, 9:336.

15.Haiying Jiang, Shuyi Luo, Jiabin Zhou, Wenzhong Huang, Linmiao Li, Xiujuan Zhang, He Jiasong, Jinping Chen*, Skin Microbiota Was Altered in Crocodile Lizards (Shinisaurus crocodilurus) With Skin Ulcer. Frontiers in Veterinary Science，2022, 9:817490.

16.Ahmad HI*, Jabbar A, Mushtaq N, Javed Z, Hayyat MU, Bashir J, Naseeb I, Abideen ZU, Ahmad N, Chen J*. Immune Tolerance vs. Immune Resistance: The Interaction Between Host and Pathogens in Infectious Diseases. Frontiers in Veterinary Science, 2022, 9:827407.

17.Ahmad HI*, Iqbal A, Ijaz N, Ullah MI, Asif AR, Rahman A, Mehmood T, Haider G, Ahmed S, Mahmoud SF, Alghamdi FO, Al Amari HA, Simirgiotis MJ, Chen J*. Molecular Evolution of the Activating Transcription Factors Shapes the Adaptive Cellular Responses to Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2022:2153996.

18.Hafiz Ishfaq Ahmad*, Gulnaz Afzal, Sehrish Sadia, Ghulam Haider, Shakeel Ahmed,Saba Saeed, and Jinping Chen*. Structural and Evolutionary Adaptations of Nei-Like DNA Glycosylases Proteins Involved in Base Excision Repair of Oxidative DNA Damage in Vertebrates, Oxidative Medicine and Cellular Longevity, 2022, 1144387: 20

19.Ahmad HI, Afzal G, Iqbal MN, Iqbal MA, Shokrollahi B, Mansoor MK and Chen J*. Positive Selection Drives the Adaptive Evolution of Mitochondrial Antiviral Signaling (MAVS) Proteins-Mediating Innate Immunity in Mammals. Frontiers in Veterinary Science. 2022, 8:814765

20.Ping Liu, Jiabin Zhou, Linmiao Li, Wenzhong Huang, Jinping Chen*, Detection of Picornavirales Viruses Using Viral Metagenomics in Wild Boars (Sus scrofa) from Guangdong Province, China, International Journal of Microbiology and Biotechnology, 2022, 7(1): 16-30.

21.Linmiao Li#; Xiaohu Wang#; Yan Hua; Ping Liu; Jiabin Zhou; Jing Chen; Fuyu An; Fanghui Hou; Wenzhong Huang; Jinping Chen*; Epidemiological Study of Betacoronaviruses in Captive Malayan Pangolins. Frontiers in Microbiology, 2021, 12: 657439.

22.Ping Liu#, Jingzhe Jiang#, Xiufeng Wan, Yan Hua, Linmiao Li, Jiabin Zhou, Xiaohu Wang, Fanghui Hou, Jing Chen, Jiejian Zou, Jinping Chen*, Are pangolins the intermediate host of the 2019 novel coronavirus (SARS-CoV-2)?, PLoS Pathogens, 2020,16(5): e1008421.

23.Hafiz Ishfaq Ahmad, Jiabin Zhou , Muhammad Jamil Ahmad , Gulnaz Afzal, Haiying Jiang, Xiujuan Zhang, Abdelmotaleb A. Elokil, Musarrat Abbas Khan, Linmiao Li, Huiming Li, Liu Ping , Jinping Chen*. Adaptive selection in the evolution of programmed cell death-1 and its ligands in vertebrates. Aging, 2020, 12(4):3516-3557.

24.Hafiz Ishfaq Ahmad, Akhtar Rasool Asif, Muhammad Jamil Ahmad, Farwa Jabbir , Muhammad Adnan, Shakeel Ahmed, Gulnaz Afzal, Ali Haider Saleem , Linmiao Li, Haiying Jiang , Mario Juan Simirgiotis , Mubashar Rauf, Jinping Chen*. Adaptive evolution of peptidoglycan recognition protein family regulates the innate signaling against microbial pathogens in vertebrates. Microbial Pathogenesis, 2020:104361.

25.Huiming Li , Ping Liu , Xiujuan Zhang , Linmiao Li, Haiying Jiang , HuaYan , Fanghui Hou, Jinping Chen*. Combined proteomics and transcriptomics reveal the genetic basis underlying the diferentiation of skin appendages and immunity in pangolin. Scientific Reports. (2020) 10:14566.

26.Huiming Li, Bize Yang, Xiujuan Zhang, Haiying Jiang, Linmiao Li, Hafz Ishfaq Ahmad, Jinping Chen*. Transcriptome analysis reveals the genetic basis underlying the development of skin appendages and immunity in hedgehog (Atelerix albiventris). Scientific Reports, (2020) 10:13920.

27.Jie Zhang* , Jiwei Qi , Fanglei Shi , Huijuan Pan , Meng Liu , Ran Tian , Yuepan Geng, Huaying Li , Yujie Qu , Jinping Chen*, Inge Seim* , Ming Li *, Insights into the evolution of neoteny from the genome of the Asian icefish Protosalanx chinensis, iScience 2020, 23, 101267

28.Haiying Jiang, Wu Chen, Li Su, Mingwei Huang, Libo Lin, Qiao Su, Guanyu Li, Hafiz Ishfaq Ahmad, Linmiao Li, Xiujuan Zhang, Huiming Li, Jinping Chen*. Impact of host intraspecies genetic variation, diet, and age on bacterial and fungal intestinal microbiota in tigers. MicrobiologyOpen. 2020, 00:e1050.

29.Hafiz I. Ahmad, Fabiana Neves, Muhammad J. Ahmad, Sunny Ahmar, Abdelmotaleb A. Elokil, Jinping Chen*. The domestication makeup: evolution, survival, and challenges. Front. Ecol. Evol. 8:103

30.Xiujuan Zhang, Jiabin Zhou, Linmiao Li, Wenzhong Huang, Hafiz Ishfaq Ahmad, Huiming Li, Haiying Jiang, Jinping Chen*. Full-length transcriptome sequencing and comparative transcriptomic analysis to uncover genes involved in early gametogenesis in the gonads of Amur sturgeon (Acipenser schrenckii). Zhang et al. Frontiers in Zoology (2020) 17:11

31.Ping Liu, Wu Chen, Jinping Chen*, Viral Metagenomics Revealed Sendai Virus and Coronavirus infection of Malayan Pangolins (Manis javanica), Viruses, 2019, 11, 979.

32.Juan Li, Haiying Jiang, Linmiao Li, Xiujuan Zhang, Jinping Chen*. The effect of       disease and season to hepatopancreas and intestinal mycobiota of Litopenaeus vannamei, Frontiers in Microbiology, 2019, 10:889. 

33.Haiying Jiang, Xiujuan Zhang, Linmiao Li, Jinge Ma, Nan He, Haiyang Liu, Richou Han, Huiming Li, Zhengjun Wu, Jinping Chen*. Identification of Austwickia chelonae as cause of cutaneous granuloma in endangered crocodile lizards using metataxonomics, Peer J, 2019, 7: e6574.

34.Lihong Yuan, Linmiao Li, Xiujuan Zhang, Haiying Jiang, Jinping Chen*.        Identification and differential expression of piRNAs in the gonads of Amur sturgeon (Acipenser schrenckii), Peer J, 2019, 7: e6709. 

35.Xiujuan Zhang, Guanyu Li, Haiying Jiang, Linmiao Li, Jine Ma, Huiming Li, Jinping Chen*. Full-length transcriptome analysis of Litopenaeus vannamei reveals transcript variants involved in the innate immune system. Fish and shellfish immunology, 2019, 87: 346-359.

36.Jinge Ma, Haiying Jiang, Linmiao Li, Xiujuan Zhang, Huiming Li, Guanyu Li; Daying Mo, Jinping Chen*. SMRT sequencing of the full-length transcriptome of the Sunda pangolin (Manis javanica), gene, 2019, 692:208-216. 

37.Wang XH, Chen W, Xiang R, Li LM, Chen J, Zhong RQ, Xiang H, Chen JP*. Complete Genome Sequence of Parainfluenza Virus 5 (PIV5) from a Sunda Pangolin (Manis javanica) in China.  Journal of Wildlife Disease，2019，55(4):947-950

38.Jinge Ma, Haiying Jiang，Linmiao Li, Xiujuan Zhang，Guanyu Li, Huiming Li, Xuejun Jin, JinPing Chen *. The fecal metagenomics of Malayan pangolin identifies an extensive adaptation to myrmecophagy.Frontiers in microbiology, 2018, 9:2793.

39.Haiying Jiang, Mingwei Huang, Libo Lin, Nan He, Jinping Chen*. Complete genome sequence of Austwickia chelonae LK16-18, isolated from crocodile lizards. Microbiology Resource Announcements, 2018, 7: e01140-18.

40.Haiying Jiang, Libo Lin, Mingwei Huang, Yingan Zang, Jinping Chen*. Genome Sequence of Morganella morganii DG56-16, Isolated from Shinisaurus crocodilurus.2019, 8(4), e01301-18.

41.Xiujuan Zhang, Jinge Ma, Linmiao Li, Haiying Jiang, Jinping Chen*. Effects of Different Cytoprotectants Combination on Sperm Survival, Fertility and Embryo Development in Amur Sturgeon (Acipenser schrenckii). Animal and Veterinary Sciences，2018; 6(4): 51-57

42.Jinge Ma, Linmiao Li, Haiying Jiang, Xiujuan Zhang, Juan Li, Guanyu Li, Jinping Chen*. Acidic mammalian chitinase gene is highly expressed in the special oxyntic glands of Manis javanica, FEBS Open Bio，2018, 8(8):1247-1255.

43.Juan Li, Linmiao Li, Haiying Jiang, Lihong Yuan, Libiao  Zhang, Jing？e Ma,  Xiujuan Zhang, Minhua Cheng, Jinping Chen*, Fecal Bacteriome and Mycobiome in Bats with Diverse Diets in South China, Current Microbiology, 2018, 75:1352–1361.

44.Xiujuan Zhang, Linmiao Li, Haiying Jiang, Jing E. Ma, Juan Li, Jinping Chen*，Identification and differential expression of microRNAs in testis and ovary of Amur sturgeon (Acipenser schrenckii), Gene, 2018,658, 36-46.

45.Zhu J, Wang X, Zhao J, Ji F, Zeng J, Wei Y, Xu L, Dong G, Ma X, Wang C. Genomic characterization and related functional genes of γ- poly glutamic acid producing Bacillus subtilis. BMC Microbiol. 2024, 24(1):125. 

46.Wang X, Zhao J, Ji F, Wang M, Wu B, Qin J, Dong G, Zhao R, Wang C. Genomic Characteristics and Molecular Epidemiology of Multidrug-Resistant Klebsiella pneumoniae Strains Carried by Wild Birds. Microbiol Spectr. 2023, 11(2):e0269122.

47.Ji F, Liu S, Wang X, Zhao J, Zhu J, Yang J, Zhang C, Jia Z, Zhao R, Hu G, Wang J, Qin J, Li G, Wu B, Wang C. Characteristics of the multiple replicon plasmid IncX1-X1 in multidrug-resistant Escherichia coli from Malayan pangolin (Manis javanica). Integr Zool. 2023, 18(2):289-298. 

48.Wang X, Kang Q, Zhao J, Liu Z, Ji F, Li J, Yang J, Zhang C, Jia T, Dong G, Liu S, Hu G, Qin J, Wang C. Characteristics and Epidemiology of Extended-Spectrum β-Lactamase-Producing Multidrug-Resistant Klebsiella pneumoniae From Red Kangaroo, China. Front Microbiol. 2020 Oct 14;11:560474

49.Kang Q, Wang X, Zhao J, Liu Z, Ji F, Chang H, Yang J, Hu S, Jia T, Wang X, Tang J, Dong G, Hu G, Wang J, Zhang Y, Qin J, Wang C. Multidrug-resistant Proteus mirabilis isolates carrying blaOXA-1 and blaNDM-1 from wildlife in China: increasing public health risk. Integr Zool. 2021 Nov;16(6):798-809.

50.Le Han, Weijun He, Huixin Yan, Xianglan Li, Chengmin Wang,Qiumei Shi, Tiezhong Zhou,Guoying Dong. The evolution and molecular characteristics of H9N2 avian influenza viruses in Jiangxi of China. Journal of Medical Virology, 2019, 91:711-716.（IF= 2.049，期刊排名：116 / 272, Medicine, 2区.第5作者）

51. Guoyao Ma, Lin Chen, Jing Luo, Bo Wang, Chengmin Wang, Meng, Chengmei Huang, Juan Du, Jiajun Ma, Yungfu Chang and Hongxuan He. Histone acetyl transferase TIP60 inhibits the replication of influenza a virus by activation the TBK1-IRF3 pathway. Virology Journal, 2018,15:172( IF= 2.464，期刊排名：91 / 272, Medicine, 2区.第5作者）

52.Meng Li,Lin Zhao,Jiajun Ma,Na Zhao,Jing Luo,Chengmin Wang,Lin Chen, Guoyao Ma,Yutian Wang,Hongxuan He. Vibrio vulnificus in aquariums is a novel threat to marine mammals and public health. Transbound Emerg Dis. 2018, 65:1863–1871. ( IF= 3.554，期刊排名：2 / 165, Veterinary, 1区.第6作者）

53.Chengmin Wang, Lyu N, Deng L, Wang J, Gu W, Ding H, Wu Y, Luo J, Wang L,Lyv X, Liu X, Tao Y and He H. Evolutionary Pattern and Large-Scale Architecture of Mutation Networks of 2009 A (H1N1) Influenza A Virus. Front. Genet. 2018, 9:204. (IF=4.151，期刊排名：31/176, Genetics & Heredity，1区，第1作者)

54.Chengmin Wang, pengpeng liu, Jing Luo, Hua Ding, yan gao, Lei Sun, fubing luo, xiaodong liu and Hongxuan He. Geldanamycin reduces acute respiratory distress syndrome and promotes the survival for of mice infected with the highly virulent H5N1 influenza virus. Front. Cell. Infect. Microbiol.2017, 7:267.IF=5.218，期刊排名：25/124, Microbiology,1区,第1作者)

55.Chengmin Wang , Huimin Liu, Jing Luo, Lin Chen, Meng Li, Wen Su, Na Zhao , Shelan Liu , Li Xie , Yaxiong Jia , Hua Ding , Xiufeng Wan , Hongxuan He. HA Triggers the Switch from MEK1 SUMOylation to Phosphorylation of the ERK Pathway in Influenza A Virus-Infected Cells and Facilitates Its Infection. Front. Cell. Infect. Microbiol. 2017,7:27. (IF=5.218，期刊排名：25/124, Microbiology,1区,第1作者)

56.Chengmin Wang, Yanyu Zhang, Jing Luo, Hua Ding, Shelan Liu, Said Amer, Li Xie,Wenting Lyv, Wen Su, Meng Li, Qinmiao Sun, Jiayin Dai & Hongxuan He.Identification of miRNomes reveals ssc-miR-30d-R_1 as a potential therapeutic target for PRRS viral infection. Scientific reports.2016 ,6:24854. （IF=5.228，期刊排名：7/62, Multidisciplinary Sciences.1区.第1作者）

57.Chengmin Wang, Jing Luo, Haijing Wang, Said Amer, Hua DING, Ying Dong, and Hongxuan He. Isolation and characterization of a Neisseria.sp from the captive wild goose (Anser anser).Integr Zool. 2016,11(2):128-33.(IF=1.722，期刊排名：38/161, Zoology,1区,第1作者)

58.Chengmin Wang, Jing Wang, Wen Su, Shanshan Gao, Jing Luo, Min Zhang, Li Xie, Shelan Liu, Xiaodong Liu, Yu Chen, Yaxiong Jia, Hong Zhang, Hua Ding, Hongxuan He. Relationship between domestic and wild birds in live poultry market and a novel human H7N9 virus in China. J Infect Dis. 2014，209(1):34-7. (IF=5.778，期刊排名：5/72,Infectious Diseases,1区,第1作者)

59.Chengmin Wang, Yanyu Zhang, Bin Wu, Shelan Liu, Ping Xu, Yanmin Lu, Jing Luo, Dale Louis Nolte, Thomas Jude Deliberto, Mingxing Duan, Hong Zhang, Hongxuan He.Evolutionary Characterization of the Pandemic H1N1/2009 Influenza Virus in Humans Based on Non-Structural Genes. PLoS ONE. 2013;8(2):e56201.(IF=3.73，期刊排名：7/56,Multidisciplinary Sciences,1区,第1作者)

60.Chengmin Wang, Jing Luo, Said Amer, Yunhai Guo, Yi Hu, Yanmin Lu, Haijing Wang, Mingxing Duan, Hongxuan He.Multivalent DNA vaccine induces protective immune responses and enhanced resistance against Cryptosporidium parvum infection. Vaccine. 2011,29, 323–328. (IF=3.572，期刊排名：25/106, Medicine, Research & Experimental，1区，第1作者)

61.Chengmin Wang, Yanyun Wu, Jianhua Qin, Haoxue Sun, Hongxuan He. Induced Susceptibility of Host Is Associated with an Impaired Antioxidant System Following Infection with Cryptosporidium parvum in Se-Deficient Mice. PLoS ONE. 2009，4(2): e4628.(.IF=4.351，期刊排名：10/76, Biology,1区,第1作者)

62.Lin Chen, Chengmin Wang, Jing Luo, Wen Su, Meng Li, Na Zhao, Wenting Lyu , Attaran H, Yapeng He, Hua Ding and Hongxuan He. Histone Deacetylase 1 Plays an Acetylation- Independent Role in Influenza A Virus Replication.Front. Immunol.2017, 8:1757 (IF=6.429,期刊排名：21/151,Immunology,1区,第1作者（共同）)

63.Shelan Liu, Chengliang Chai, Chengmin Wang, Said Amer,Huakun Lv, Hongxuan He, Jimin Sun and Junfen Lin.Systematic review of severe fever with thrombocytopenia syndrome: virology, epidemiology, and clinical characteristics. Reviews in Medical Virology. 2014，24: 90–102 (IF=5.759,期刊排名：5/33,Virology,1区,第1作者（共同）)

64.Bin Wu, Chengmin Wang, Guoying Dong, Yunhai Guo, Dale Louis Nolte, Thomas Jude Deliberto, Jianguo Xu,Mingxing Duan, Hongxuan He.New Evidence Suggests Southern China as a Common Source of Multiple Clusters of Highly Pathogenic H5N1 Avian Influenza Virus. Journal of Infectious diseases. 2010，202:452–458(IF=6.228,期刊排名：5/58,Infectious Diseases,1区,第1作者（共同）)

65.Chengmin Wang, Jing Luo，Jing Wang，Wen Su, Shanshan Gao, Min Zhang, Li Xie，Hua Ding，Shelan Liu，Xiaodong Liu，Yu Chen，Yaxiong Jia，Hongxuan He. Novel human H7N9 influenza virus in China. Integrative Zoology.2014，9: 372–375 (IF=1.419,期刊排名：47/153, Zoology,2区,第1作者)

66.Chengmin Wang，Hongxuan He Leptospira spp. In Commensal Rodents, Beijing, China. J Wildl Dis. 2013，49(2):461-3. (IF=1.271,期刊排名：48/143, Veterinary Sciences,2区,第1作者)　

授权发明专利：

1.江海英、陈金平、黄铭威、林立波、李林妙、张秀娟、李官钰。国家发明专利：龟嗜皮菌特异性鉴定引物、试剂盒及其鉴定方法，专利号：ZL201910257052.X，授权日：2023.4.21

2.张秀娟、陈金平、吴文化、俞也频、江海英、韩勍、李林妙。国家发明专利：miR-34b/c基因抑制剂在调控施氏鲟早期性别分化中的应用，专利号：ZL202210891797.3，授权日：2023.07.18。

3.张秀娟、陈金平、吴文化、周佳滨、李林妙、江海英。日本发明专利：チョウザメの性別を同定するｍｉｃｒｏＲＮＡ血清マーカー、プライマーセット、キット及びその応用，专利号特许第7090357号。

4.李慧明、陈兴永、陈金平、苏力、胡倩雯。国家发明专利：一种用于坡鹿亲子鉴定的SSR荧光标记引物和鉴定方法，专利号：ZL202010548407.3, 授权日：2022.5.10

5.陈金平、李慧明、李林妙、晋学君。国家发明专利：用于穿山甲亲子鉴定的SSR荧光标记引物及应用，专利号：ZL2018112207932, 授权日：2021.11.30

6.陈金平，李林妙，覃茂林，刘灯红. 国家发明专利：一种施氏鲟雌鱼和匙吻鲟雄鱼杂交育苗方法. 专利号：ZL201710698134.9；授权公告日：2020.1.7.

7.张秀娟、陈金平、吴文化、周佳滨、李林妙. 国家发明专利：江海英鉴定鲟鱼性别的microRNA血清标志物、引物组、试剂盒及其应用. 专利号：ZL202010314533.2；授权公告日：2020.7.24.

8.张秀娟、陈金平、白银山、张守全、王承民. 国家发明专利：一种利用FACT Ⅲ微载体体外扩增精原干细胞的三维动态培养方法. 专利号：ZL202010314524.3；授权公告日：2020.7.31.

9.原丽红，李林妙.日本专利：一条D螺旋区突变的瘦素活性肽及其编码基因和应用.专利号：特许第6486482号;授权公告日：2019.3.1.

10.原丽红，李林妙.日本专利：一条D螺旋区突变的瘦素活性肽及其编码基因和应用.专利号：ZL201510228121.6;授权公告日：2017.11.28.

11.原丽红，陈金平. 国家发明专利：一条 CD 环和 E 螺旋区突变的瘦素活性肽及其编码基因和应用.专利号：ZL201510228093.8；授权公告日：2017.11.06.

12.原丽红，张树义，陈金平，林本夫，左学国，何灵江. 国家发明专利：棕果蝠瘦素蛋白及其cDNA序列. 专利号：ZL200910039440.7; 授权公告日：2011.08.24.

13.原丽红，张树义，林本夫，何灵江，左学国，陈金平. 国家发明专利：马铁菊头蝠瘦素蛋白及其cDNA序列. 专利号：ZL200910039438.X, 授权公告日：2011.09.28.

14.原丽红，张树义，林本夫，左学国，何灵江，陈金平. 国家发明专利：长翼蝠瘦素蛋白及其cDNA序列, 专利号：ZL200910039439.4, 授权公告日：2011.08.24.

15.吴文化，孙大江，张颖，宋聃，陈金平，王念民. 国家发明专利：一种达氏鳇苗种的低温驯化培育方法, 专利号：ZL201310533824.0, 授权公告日：2016.03.23.

16.Chengmin Wang，Zhihui Liu，Jianan Zhao，Xue Wang，Jianhua Qin. 荷兰发明专利:Screening Method of Bacteria Having A Phosphorus Solubilization Function, 专利号：NL2026576, 授权公告日：2021.07.12

17.Chengmin Wang，Zhihui Liu，Jianan Zhao，Xue Wang，Jianhua Qin. 荷兰发明专利:Preliminary Screening Method of Bacteria Having an Ammonia Nitrogen Degradation Function, 专利号：NL2026574, 授权公告日：2021.08.20

18.王承民;季芳;赵佳男;徐莉莉. 国家发明专利: 重金属抗性菌及其应用, 专利号：ZL202111300831.7, 授权公告日：2022.06.21

19.王承民;赵佳男;季芳;曹洪杨;徐莉莉。 国家发明专利: 耐铅菌及其应用, 专利号：ZL202111311685.8, 授权公告日：2022.08.19

20.王承民，季芳，赵佳男，王雪，曹洪杨，徐莉莉。国家发明专利: 一种重金属抗性的木糖氧化无色杆菌及其应用, 专利号：ZL 202210850133.2, 授权公告日：2022.11.28

21.王承民，季芳，王雪，赵佳男，徐莉莉。国家发明专利: 一种重金属抗性的高地芽孢杆菌及其应用, 专利号：ZL 202210850167.1, 授权公告日：2022.12.06

22.王承民，季芳，赵佳男，王雪，魏磊，王猛，张秀娟，李林妙，贾仲昕。国家发明专利: 重金属抗性菌及其应用, 专利号：ZL202210028386.1, 授权公告日：2023-01-09

23.王承民，季芳，赵佳男，王雪，曹洪杨，徐莉莉。国家发明专利: 一种耐受重金属的罗尔斯顿菌及其应用, 专利号：ZL202210849603.3, 授权公告日：2023-01-17

24.王承民，贾仲昕，王雪，赵佳男，季芳，王猛，张立敏，胡国成，武斌。国家发明专利: 产中性蛋白酶芽孢杆菌和利用其生产中性蛋白酶的方法, 专利号：ZL202210059357.1, 授权公告日：2023-02-23

25.王承民,季芳,赵佳男,王雪,徐莉莉,曹洪杨,胡国成。国家发明专利: 一种具有重金属去除功能的嗜麦芽窄食单胞菌及其应用, 专利号：ZL202211199532.3, 授权公告日：2023-03-16

26.王承民，赵佳男，王雪，季芳，曹洪杨，胡国成，李良忠，徐莉莉。国家发明专利: 一种耐铅的短小芽孢杆菌及其应用, 专利号：ZL202210850185.X, 授权公告日：2023-04-20